There’s a reason NAD+ keeps showing up in nearly every serious longevity conversation right now. Researchers, formulators, and wellness experts alike continue returning to the same conclusion: cellular energy plays a foundational role in how we age, recover, think, and function. At the center of that conversation is NAD+, a coenzyme involved in mitochondrial function, ATP production, DNA repair, and stress response pathways throughout the body.
As interest in longevity and foundational wellness grows, so does curiosity around what happens when NAD+ levels begin to decline over time. For years, Cymbiotika cofounder and Chief Science Officer Chervin Jafarieh has focused on the connection between cellular energy, resilience, and the cumulative effects of modern life on the body. That philosophy ultimately became the foundation for Cymbiotika’s Liposomal NAD+, a formula designed not just around NAD+ itself, but around delivery, absorption, and supporting the broader systems connected to cellular repair and energy production.
“If something isn’t absorbed well, it doesn’t matter how good it looks on paper,” says Jafarieh. “The whole point is getting these compounds into the body in a way that they can actually be used.”
Why NAD+ Matters
NAD+, short for nicotinamide adenine dinucleotide, is found in every living cell and helps the body convert nutrients into ATP, the primary source of cellular energy. Beyond energy production, it also plays a role in mitochondrial efficiency, DNA repair, metabolic function, cognitive performance, and the body’s ability to respond to stress over time, which is part of why it has become such a major focus in both wellness and longevity conversations.
“When you strip away all the marketing nonsense we are all bombarded with and just follow the biology, you keep landing in the same place: NAD+,” says Jafarieh. He explains that NAD+ levels naturally decline with age while stress, poor sleep, artificial light, parasite infestation, toxin exposure, and the pace of modern life may accelerate that process.
“When that happens, it’s not just that you ‘feel tired,’” he says. “It’s that your cellular efficiency starts to slip. Energy, metabolism, clarity, recovery, even the way your skin looks.”
That growing connection between cellular function, recovery, and resilience is a large part of why conversations around NAD+ have expanded so quickly in recent years, especially as more people begin looking beyond quick energy fixes and toward more foundational support.
Why Delivery Matters
For Jafarieh, the conversation around NAD+ was never just about dosage. The bigger question was whether the body could actually absorb and utilize it effectively, because even the best ingredients mean very little if they are not properly delivered within the body.
“Dose alone isn’t enough,” he says. “Delivery matters just as much.”
That belief shaped Cymbiotika’s approach to Liposomal NAD+, which contains 300 mg of pure NAD+ intended to meaningfully support mitochondrial energy production and cellular repair pathways rather than simply adding a small amount for label appeal.
“We didn’t put a sprinkle of NAD+ in here so we could put it on a label,” says Jafarieh. “I don’t believe in under-dosing. I never have.”
To help support absorption and utilization, the NAD+ is encapsulated within Cymbiotika’s liposomal matrix using 60 mg of pure, sunflower-derived phosphatidylcholine rather than generic lecithin blends or soy-based fillers. According to Jafarieh, that distinction matters because phosphatidylcholine supports cellular structure, nervous system health, and cognitive function in addition to helping form the liposome itself.
“Phosphatidylcholine is what your cell membranes are made of,” he explains. “The choline backbone contributes to acetylcholine production, which plays a role in memory and focus. So it’s not just there to form a liposome. It adds real value to the formula.”
Supporting the Whole System
One of the core ideas behind the formula is that energy production does not happen in isolation, which is why Cymbiotika approached the formula with a broader systems-based philosophy rather than focusing narrowly on NAD+ alone.
“If you push one pathway without supporting the others, you create imbalance,” says Jafarieh. “Biology doesn’t work in isolation.”
That thinking shaped the rest of the formula, including the addition of TMG to support methylation pathways connected to detoxification, neurotransmitter production, cardiovascular balance, and liver function. The formula also contains apigenin to support recovery and nervous system balance, something Jafarieh sees as equally important to the energy conversation itself.
“Energy without recovery is a recipe for burnout,” he says. “Supporting the nervous system matters. Repair matters.”
Liposomal NAD+ also includes Lutemax®, naturally derived caffeine from green coffee bean, and niacin to support NAD+ metabolism, while the flavor system uses organic vanilla extract, organic orange terpenes, organic cocoa extract, and Icelandic sea salt instead of artificial masking agents or synthetic fillers.
A More Foundational Approach
In many ways, the growing interest in NAD+ reflects a broader shift happening across wellness as people become less interested in quick fixes and increasingly focused on recovery, resilience, mitochondrial health, nervous system regulation, and foundational support.
For Jafarieh, that larger philosophy ultimately shaped the formula itself.
“This formula is about fueling the body properly and supporting cellular repair consistently,” he says. “When you give the cell what it needs, the whole system responds.”
